Sellabus
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SEMESTER -3 (OrganicChemistry)
CHE(O) 501
Natural Products and Biomolecules
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Unit I : Natural pigment
Natural colouring matter, general classification, method of synthesis, biosynthesis studies of anthocyanins (cyanine) flavones (chryosin) and flavanol (Querecetin)
Porphyrin-structure, spectral properties and synthesis, general and structure determination of Haemoglobin, chlorophyll and Bilirubin.
Unit II : Alkaloids and vitamins
Alkaloids: General biogenetic studies of alkaloids, chemistry of quinine, morphine , reserpine and colchicine
Vitamins : Introduction, synthesis and biochemical function of vitamin B(Thiamine), Vitamin H and α -tocopherol (Vitamin E), vitamin C.
Unit III: Steroids and hormones
General biosynthesis studies of steroids, structure of cholesterol and ergosterol (No synthesis). Stereochemistry of steroids, chemistry of bile acids.
Chemistry of androgens, oestrogens and gestrogens, their synthesis and biochemical role. Adrenocortical hormones, partial synthesis of cortisone.
Unit IV: Terpenoids and carotenoids
Classification, nomenclature, general methods of structure determination, chemistry and synthesis of abietic acid and gibberellic acid (gibberllin-A), farnesol, zingeberine and squalene. Biosynthetic studies on triterpenoids and tetraterpenoides.
Reference books:
1. Organic chemistry vol I & II (sixth edition) I.L.Finar
2. Chemistry of vitamins-S.F.Dyke
3. Chemistry of natural products by Bantely, Vol 1-10
4. L.J.Wade Jr. Organic chemistry, Prentice nall, England cliffs, 1987
5. Chemistry of Natural products vol I & II by O.P.Agrawal
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SEMESTER -3 (OrganicChemistry)
CHE(O) 502
Medicinal Chemistry
General classification, structural variations, synthesis and medicinal uses of the following classes of drugs.In addition to the above structure Activity Relationships and Mode of Action should be discussed in classes wherever it is mentioned.
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Unit I : Antibiotics
Antibiotics that interfere with the biosynthesis of bacterial cell wall.
A. The β -lactum antibiotics : Penicillin and cephalosporin
B. Non lactum antibiotics (only name and structures)
C. Bacitracin, vancomycin and cycloserine (only name and structures)
Antibiotics that interfere with the protien biosynthesis in microorganisms : non lactum antibiotics, tetracycline, chloroamphenicol
Structure actively relationship (SAR) among penicillinis and tetracyclins
Non classifiable antibiotics (only structure and therapeutic uses)
Synthesis of pencillin V, ampicillin, cephalosporin and chloroamphenicol.
Unit II : Psychoactive drugs
CNS depressant:
A. General and local anaesthetics
B. Sedative and hypnotics
Antipsychotic drugs
A. Antidepressant
B. Neuroleptics
Synthesis of the following
Thiopental, amobarbital, diazepam, chlorozepan, alprazolam, glutethimide, nikethamide, procaine, lidocaine and dibucaine, Ibuprofin, meclofenate sodium, novalgin, pethidine
Unit III: Antimalarial and Antituberculosis drugs
Antimalarials: Modern chemotherapy of malaria, 4-amino and 8-amino quinolins, 9-amino acridine.
Synthesis of mefloquines, chloroquine, primaquine and daraprim
Mode of action of antimalarial agents
SAR of antimalarial agents
Anti tuberculosis: Synthesis of only the following drugs:
Isoniazid (INH), Ethionamide, Ethambutol, DDS (Dapsone)
Unit IV :Cardiovascular, diuretics and hypoglycemic agents
Synthesis of amyl nitrate, diltiazim, atenolol, methyl dopa, tolbutamide, chloropropamide, glibenclamide, acetazolamide, chlorothiazide, furosemic and ethacrycnic acid
Reference books:
1. Burger’s medicinal chemistry and drug design (5/e) 1997, vol 1 to 5 edited by Manfred E.Woltt (John wiley and sons Mc. New york)
2. Principles of medicinal chemistry by William A. Foye (ied), lea and febiys (Philadelphia)
3. Principles of medicinal chemistry vol I & II (5/e) F.S.kadam, K.R. Mahadic ad K.G.Bohra (Nirali publication)
4. Medicinal chemistry by ashutosh kar
5. The organic chemistry of drug synthesis vol I, II and III (1980) ed by D. lednicer and L.A. mitscher (Johyn wiley and sons, New york)
6. Wilson and Gisvold text book of organic medicinal and pharmaceutical chemistry (5/e,1982) by Robert Doerge (J.B. lippincoff company, phaladophia/ Toppan co.Ltd, Tokyo)
7. Topics in medicinal chemistry vol I & II by rabinowitz Myerson (interscience 1968)
8. The pharmaceutical basis of theraperutics by Geoman and Gilman (Mcmillan co.)
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SEMESTER -3 (OrganicChemistry)
CHE(O) 503
Organic Spectroscopy
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Unit I :UV & IR
UV: Electronic transitions, chromophores, auxochromes, bathochromic and hypsochromic shifts, solvent effects, wood ward fieser rules for dienes, enones and aromatic compounds applications of U.V., instrumentation.
I.R. Vibrational transitions, important group frequencies, factors affecting I.R. group frequency, applications of I.R. instrumentation
Unit II : NMR
Elementary ideas of NMR integration, chemical shifts, Factors affecting, chemical shifts, coupling (first order, analysis) instrumentation and principles and instrumentation, FT, chemical shifts, spin-spin coupling different spin systems, mechanism of spin coupling. E.q. AB, ABX, factors affecting vicinal and geminal couplings, rate processes, long range couplings, spin decoupling, shift reagents, solvent shifts, nuclear overhauser effect. 2D NMR (COSY and HETCOR) applications.
Unit III: C13 NMR and Mass spectrometry
C13 NMR: elementary ideas, instrumental problems ,chemical shift features of hydrocarbons, effect of substituent on chemical shifts olefinic, acetylenic, aromatic and carbonyl carbons, effects of coupling
Mass spectrometry: theory, instrumentation, modes of ionization, types of detectors, modes of fragmentation. Different types of ions, molecular ions, isotopic peaks, factors controlling fragmentation, hyphenated mass spectroscopy techniques.
Unit IV:
Structural elucidation of drug molecules based on joint application of UV,IR, PMR, CMR and mass spectroscopy.
Reference books:
1. Spectroscopic methods in organic chemistry, D.H.Williams and Tan fleming
2. Spectrometric identification of organic compounds, T.C.Morril R.M.Silverstein and G.Bassler, 6th edition, John Wiley and sons
3. Introduction to spectroscopy, D.L.Pavia, G.M.Lampman and G.S.Kriz, 3rd edn, Harcourt college publishers.
4. Organic spectroscopy by W.Kemp
5. Organic spectroscopy by P.S.Kalsi
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SEMESTER -3 (OrganicChemistry)
CHE(O) 504
Industrial Chemistry
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Unit I : Basic principles
Basic chemical data, batch versus continuous operation, design, flow charts, chemical process selection, safely, hazardous, fire toxic materials, research and development patents, good manufacturing practice and laboratory practice.
Unit II: Unit processes in organic chemistry
Nitration, sulfonation, halogenation, amination and alkylation methods and industrial chemicals derived from benzene, naphthalene and anthracene using unit process.
Unit III
Green chemistry -12 principles of green chemistry
Green solvents- aqueous phase reactions Wurtz reaction, witting-Horner reaction, Michael reaction
- Solid phase reactions: halogenation, aldol condensation, grignard reaction.
- Ionic liquid as green solvent- hydrogenation, diels-alder reaction, o- alkylation and N-alkylation
Green catalysts of green reagents (introduction)
Unit IV
Manufacture and uses of
-Argochemics (insecticides, fungicides, plant nutrients and plant hormones, Weedicides, pesticides)
-Unit operations
Reference books:
1. Unit processes in organic synthesis by P.H.Groggins
2. Industrial Chemical process by R.N.Shreve
3. Riegels handlook of industrial chemistry ed by James and Kent
4. Dryden’s outlines of chemical Technology M.Gopal Rao
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SEMESTER -3
Organic Chemistry - Practicals
CHE(O) 505 & 506 PR
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Preparation of industrially important compounds by following name reactions
(mechanism, purification and characterization of the synthesized compounds)
1. Sandmeyer reaction
2. Pechmann reaction
3. Skraup synthesis
4. Riemer-Tiemann reaction
5. Kolbe-smith reaction
6. Claisen-smith synthesis
7. Hoffman reaction
8. Diels-alder reaction
9. Green –bromination
Estimation
1. Drug assay (estimation of sulpha drug)
2. Non-aqueous titration
3. Nitrite value
4. Drug dissolution
Reference books:
1. Quantitative analysis by Arther I.Vogel
2. Quantitative analysis by V.K.Ahluwalia
3. Quantitative analysis by Mann and sanders
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